2-Bromo-5 chloraldehyde
2-Bromo-5-chlorobenzaldehyde
CAS: 174265-12-4
Molecular Formula: C7H4BrClO
2-Bromo-5 chloraldehyde - Names and Identifiers
| Name | 2-Bromo-5-chlorobenzaldehyde |
| Synonyms | 2-Bromo-5 chloraldehyde 2-Bromo-5-chlorobenzalde 5-Chloro-2-bromobenzaldehyde 2-Bromo-5-chlorobenzaldehyde Benzaldehyde,2-bromo-5-chloro- |
| CAS | 174265-12-4 |
| EINECS | 678-212-3 |
| InChI | InChI=1/C7H4BrClO/c8-7-2-1-6(9)3-5(7)4-10/h1-4H |
| InChIKey | IIISHLMCTDMUHH-UHFFFAOYSA-N |
2-Bromo-5 chloraldehyde - Physico-chemical Properties
| Molecular Formula | C7H4BrClO |
| Molar Mass | 219.46 |
| Density | 1.698 |
| Melting Point | 66 °C |
| Boling Point | 258 °C |
| Flash Point | 110 °C |
| Vapor Presure | 0.014mmHg at 25°C |
| Appearance | Crystallization |
| Color | Pale yellow |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.623 |
| MDL | MFCD00462870 |
2-Bromo-5 chloraldehyde - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN1993 |
| HS Code | 29130000 |
2-Bromo-5 chloraldehyde - Reference Information
| introduction | 2-bromo -5-chlorobenzaldehyde is an important pharmaceutical intermediate that can be used in the synthesis of a variety of drugs. 2-Bromo-5-chlorobenzaldehyde can be used to prepare compound 3-chloro-14-cyclohexyl-6-[2-(dimethylamino) ethyl] -7-oxo-5, 6,7, 8-tetrahydro< br> Indole [2,1-a][2,5] benzodiazin-11-formic acid, this compound can be used to treat or prevent viral infections. |
| preparation | concentrated sulfuric acid (mass fraction 98%,150mL) is put into the reaction kettle to cool down under stirring, the system temperature is controlled ≤ 10 ℃, compound a liquid (3-chlorobenzaldehyde, 0.5mol) is slowly added dropwise, after adding, an appropriate amount of catalyst I2(0.236-2.36mmol) is added, this embodiment is 30mg), when 3-chlorobenzaldehyde and catalyst I2 are added, there is obvious heat release phenomenon, and the reaction temperature of the system should be controlled to be ≤ 10 ℃; The temperature of the system is controlled to be ≤ 15 ℃, and NBS(N-bromosuccinimide, 0.5mol) is added in batches for 5-10 times; The heat preservation reaction was carried out for 2 hours, slowly rose to 25 ℃, and then stirred for 1 hour, GC detected the content of raw material 3-chlorobenzaldehyde ≤ 1%, and the reaction solution was post-processed and purified to obtain needle-like white solid compound B, I .e. 2-bromo -5-chlorobenzaldehyde 98g, with 98.0% purity and 90.1% yield. |
Last Update：2024-04-09 21:01:54
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